	   SnapGene      àGACGGATCGGGAGATCTCCCGATCCCCTATGGTGCACTCTCAGTACAATCTGCTCTGATGCCGCATAGTTAAGCCAGTATCTGCTCCCTGCTTGTGTGTTGGAGGTCGCTGAGTAGTGCGCGAGCAAAATTTAAGCTACAACAAGGCAAGGCTTGACCGACAATTGCATGAAGAATCTGCTTAGGGTTAGGCGTTTTGCGCTGCTTCGCGATGTACGGGCCAGATATACGCGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTCTGGCTAACTAGAGAACCCACTGCTTACTGGCTTATCGAAATTAATACGACTCACTATAGGGAGACCCAAGCTGGCTAGCGTTTAAACTTAAGCTTGGTACCGAGCTCGGATCCGCCACCatgatcgccgcgcagctcctggcctattacttcacggagctgaaggatgaccaggtcaaaaagattgacaagtatctctatgccatgcggctctccgatgaaactctcatagatatcatgactcgcttcaggaaggagatgaagaatggcctctcccgggattttaatccaacagccacagtcaagatgttgccaacattcgtaaggtccattcctgatggctctgaaaagggagatttcattgccctggatcttggtgggtcttcctttcgaattctgcgggtgcaagtgaatcatgagaaaaaccagaatgttcacatggagtccgaggtttatgacaccccagagaacatcgtgcacggcagtggaagccagctttttgatcatgttgctgagtgcctgggagatttcatggagaaaaggaagatcaaggacaagaagttacctgtgggattcacgttttcttttccttgccaacaatccaaaatagatgaggccatcctgatcacctggacaaagcgatttaaagcgagcggagtggaaggagcagatgtggtcaaactgcttaacaaagccatcaaaaagcgaggggactatgatgccaacatcgtagctgtggtgaatgacacagtgggcaccatgatgacctgtggctatgacgaccagcactgtgaagtcggcctgatcatcggcactggcaccaatgcttgctacatggaggaactgaggcacattgatctggtggaaggagacgaggggaggatgtgtatcaatacagaatggggagcctttggagacgatggatcattagaagacatccggacagagtttgacagggagatagaccggggatccctcaaccctggaaaacagctgtttgagaagatggtcagtggcatgtacttgggagagctggttcgactgatcctagtcaagatggccaaggagggcctcttatttgaagggcggatcaccccggagctgctcacccgagggaagtttaacaccagtgatgtgtcagccatcgaaaagaataaggaaggcctccacaatgccaaagaaatcctgacccgcctgggagtggagccgtccgatgatgactgtgtctcagtccagcacgtttgcaccattgtctcatttcgctcagccaacttggtggctgccacactgggcgccatcttgaaccgcctgcgtgataacaagggcacacccaggctgcggaccacggttggtgtcgacggatctctttacaagacgcacccacagtattcccggcgtttccacaagactctaaggcgcttggtgccagactccgatgtgcgcttcctcctctcggagagtggcagcggcaagggggctgccatggtgacggcggtggcctaccgcttggccgagcagcaccggcagatagaggagaccctggctcatttccacctcaccaaggacatgctgctggaggtgaagaagaggatgcgggccgagatggagctggggctgaggaagcagacgcacaacaatgccgtggttaagatgctgccctccttcgtccggagaactcccgacgggaccgagaatggtgacttcttggccctggatcttggaggaaccaatttccgtgtgctgctggtgaaaatccgtagtgggaaaaagagaacggtggaaatgcacaacaagatctacgccattcctattgaaatcatgcagggcactggggaagagctgtttgatcacattgtctcctgcatctctgacttcttggactacatggggatcaaaggccccaggatgcctctgggcttcacgttctcatttccctgccagcagacgagtctggacgcgggaatcttgatcacgtggacaaagggttttaaggcaacagactgcgtgggccacgatgtagtcaccttactaagggatgcgataaaaaggagagaggaatttgacctggacgtggtggctgtggtcaacgacacagtgggcaccatgatgacctgtgcttatgaggagcccacctgtgaggttggactcattgttgggaccggcagcaatgcctgctacatggaggagatgaagaacgtggagatggtggagggggaccaggggcagatgtgcatcaacatggagtggggggcctttggggacaacgggtgtctggatgatatcaggacacactacgacagactggtggacgaatattccctaaatgctgggaaacaaaggtatgagaagatgatcagtggtatgtacctgggtgaaatcgtccgcaacatcttaatcgacttcaccaagaagggattcctcttccgagggcagatctctgagacgctgaagacccggggcatctttgagaccaagtttctctctcagatcgagagtgaccgattagcactgctccaggtccgggctatcctccagcagctaggtctgaatagcacctgcgatgacagtatcctcgtcaagacagtgtgcggggtggtgtccaggagggccgcacagctgtgtggcgcaggcatggctgcggttgtggataagatccgcgagaacagaggactggaccgtctgaatgtgactgtgggagtggacgggacactctacaagcttcatccacacttctccagaatcatgcaccagacggtgaaggaactgtcaccaaaatgtaacgtgtccttcctcctgtctgaggatggcagcggcaagggggccgccctcatcacggccgtgggcgtgcggttacgcacagaggcaagcagcCTCGAGGATTACAAGGATGACGACGATAAGTAGTGAGGGCCCGTTTAAACCCGCTGATCAGCCTCGACTGTGCCTTCTAGTTGCCAGCCATCTGTTGTTTGCCCCTCCCCCGTGCCTTCCTTGACCCTGGAAGGTGCCACTCCCACTGTCCTTTCCTAATAAAATGAGGAAATTGCATCGCATTGTCTGAGTAGGTGTCATTCTATTCTGGGGGGTGGGGTGGGGCAGGACAGCAAGGGGGAGGATTGGGAAGACAATAGCAGGCATGCTGGGGATGCGGTGGGCTCTATGGCTTCTGAGGCGGAAAGAACCAGCTGGGGCTCTAGGGGGTATCCCCACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGCAGCGTGACCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTTCCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGGGGCTCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAACTTGATTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTTTCGCCCTTTGACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAACTGGAACAACACTCAACCCTATCTCGGTCTATTCTTTTGATTTATAAGGGATTTTGCCGATTTCGGCCTATTGGTTAAAAAATGAGCTGATTTAACAAAAATTTAACGCGAATTAATTCTGTGGAATGTGTGTCAGTTAGGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCAGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCATAGTCCCGCCCCTAACTCCGCCCATCCCGCCCCTAACTCCGCCCAGTTCCGCCCATTCTCCGCCCCATGGCTGACTAATTTTTTTTATTTATGCAGAGGCCGAGGCCGCCTCTGCCTCTGAGCTATTCCAGAAGTAGTGAGGAGGCTTTTTTGGAGGCCTAGGCTTTTGCAAAAAGCTCCCGGGAGCTTGTATATCCATTTTCGGATCTGATCAAGAGACAGGATGAGGATCGTTTCGCATGATTGAACAAGATGGATTGCACGCAGGTTCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACAGACAATCGGCTGCTCTGATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGTCCGGTGCCCTGAATGAACTGCAGGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCGCAGCTGTGCTCGACGTTGTCACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCAGGATCTCCTGTCATCTCACCTTGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGCTGCATACGCTTGATCCGGCTACCTGCCCATTCGACCACCAAGCGAAACATCGCATCGAGCGAGCACGTACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAAGAGCATCAGGGGCTCGCGCCAGCCGAACTGTTCGCCAGGCTCAAGGCGCGCATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCGATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTGGGTGTGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCGAATGGGCTGACCGCTTCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTATCGCCTTCTTGACGAGTTCTTCTGAGCGGGACTCTGGGGTTCGAAATGACCGACCAAGCGACGCCCAACCTGCCATCACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGGAATCGTTTTCCGGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTGGAGTTCTTCGCCCACCCCAACTTGTTTATTGCAGCTTATAATGGTTACAAATAAAGCAATAGCATCACAAATTTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAATGTATCTTATCATGTCTGTATACCGTCGACCTCTAGCTAGAGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTGACGTC  EÁ   .   4      +   2   ,   /   "   /            '   )   3   &   -   &          1   #         /         1   '      !   %   <                              !          !         '         #   /             8      *   /   "   /   "   '   '   /      (      &   $      #                )   '      /   (      "   (   @   "      (                        +   .      &                      !         /   (                      %         #                         /   6   *   2   "   !   '   0   (                  '   /                                    "               %   %                             -   *         $   .                  &   )   $   '      $   '   %   #   &      !      !   $                                 (   /   $   #      1   )   %          )      #   *            #   5   +   %   -               %      %   $      +   %   +             2   /   #   %       0               %      %        . šøŸ¹ûôõ~	Z
’
Ö×ßùúûËQ45<=>CHWXy§°±UV'ê'©Ç4¶g£µ4  š1›½ÙoI’=mù ºïü5�àÇ	
[
“
Ú
$žØLŸ¹ÃYbz&ÈŒª5·´Œ\ûf3 · °®Äò
uR?D²Ûc•‚-}(Èh{¶+ Ø �$_o=^ön		S
­

dàü¯Ìa6L�I„¨W¨H€Ü(ëÄxJü`¼¤;2 	 d -´¾pÏ2“ì>IÂËx—¡»Äð6\}áæâ0	Z	x	¹	ë	3¸»ÊÓô^ºZÑŸ«É1·6], .QÇ{“Ž¹†	î	
&
\
Û
:Mûëc™ùqˆÐ½S±Âçmµêx¸ü•4D/  ‡œ ØJ¤n¤Íýsƒh	ä	”
£
% ‰%py]{'Þðö-¹Ò#f˜«¸šsG�¨g´Ž" ›2Ú[«úàoN	È	‰
Ô
ë
F’ŸÙ 6Ÿ¤¿ÄNç¸Û†’ �O/  ±e«Å�.zÁ 			]	Ó	
#
LÐ3vSVõï,@E�Üá–ƒË.¤P~É>ä�£A E¿”Vj³Þˆ�×-Gl‚ÉöT ¸ mŽõ>vŸ	ó
ŽƒTädœ¼?ˆ)tâ'>¥ižÝ|· g áy¯Ö#U!Ässêi”ðÍ«' ½ ‚p>¥º	rM–ÊØ�Ýk6ƒº½h;K�š A`½ŠyE[¥<) � Ï@sÊ%^dƒ*_éï&	T
û
e¤á°Íx)/aJqy èI¾)_9ã 3 • U6Q}‡71i÷9	€	®
O}…�©<X”ÜW¢´6>YrÆÏ]n�ìyžÅy”{ý±a–Y& Ù LÀ?šRV`½		o	Þ	œ
ýb7F�©7tz®%ÓZu)×âô¦m½È- e ó˜öy��¢]‹.	[	f	„	ì	8}Œ¹Ô­_�#_n�[”rx� ¬ô4¼!9<€^& 
 ?q3”Õ?J˜Åñ7ã1	s	º	Í	
46¼Ë[»Öî–ê2LS7š†6Ä n .µ¿í5ÃåâåÎ
õð»'Ò¸Ó<–ñæ| L  y -šÐ¾Ì¼9~ç	y	`
€JŠÊ©­â´b¬×„Ï|ÁŠ1 © Õ/8RaÈL”Öl�º`	c	‡	]
Á]œÃøìd¤ì•¾ß±²n¶ž»ÚPÉ¹Èý¾n# Y�×L®Ï

'
H
Nyš‰ÑNœT.pˆ	ÃDë?}–¨E¥Ë ¬ ;»Îàµ³Ï	Ü
;:&­ådr¬GÀ€$°85Mš A|I¼	ï	
Ä˜üžú°úÇè	¾y~/ 8 Ñ hÙ5e„•Ñ-¥Ê SŸðóÎi	u	¥	¤
&m¾Íå`3&z|™ñbaºÓ9™Ð Þ ˆóV*	+Šƒµ¨¹Y›NW~h� ð �êK–Ao´¡øq^j�(1OgíU[t4Žœ�1    ¡®¥)U£W‹ÎþGt„å	5
i
•
ã
c´ê�¢ßä÷.|ÍÖ$œ¬ HS[©µs…³µÆê'   r~§ú´þ=šÇ€‘	�	Ä	Ë
Õ
G7½Àò}€¹Ë¹ÙõÜ?Ž/nÙ ž ê îü\¬ÙáëO	ì
\!+6GÅOgìR“KLõ?! ÷ œ3“Ûd#ûCö²ÈÖ	�
Š
“/‘ ³¬è[Do!ePQ>% š Yd)sÜ0@÷×p3	É	Ap ÚÆØô¥åó�—›‘/‡É37VŠˆH< ²…¬kÅÔ"5‘(ä/ç
	�	
$
é
JMSbÈÑ÷4hTp‡·½JAF‚ßâ¦åo†Î/ÍQs�%?»¡¤vË? fÌJ�T	^	Ô	
Šwò±ö‹ñ—›-¦†ÕÍ ] _ Ü¨¢ú{û	KWn-Ývx„Ìk„¼åIBÏ=  s Æ7ÂÑý	uèMP°Úðp¥ï"ÕÊyŽt’‰ÞÐ p 
ˆ)Å£˜Ôç‡÷K
 FŽÀëuk¾ží.HmèÁÓ L �·ÞNóª�Wk:´§ïÐRß<LE‰ØƒÃÊÞU?ž * Ô Óì#Dw•/o³" a ç h/w�›„ºÈÎø›u"ìúó7õ'*�·ÅNÁJ C ¹ ü 7d 	Uå@~ãŽ¦á‡ù~ŸÑÞ}! À n�ÁÅ„övç’¨e
ô
Þ•Ë½û…Ï(}?c&ÌP  0…ä?¶
5e�Úï@m‰àÿ*ºw…àî˜,jœÌ¸ h èO}Ê*StëFM! uªýT·â`×$N¤VB/FzÀv’û6t8•Dºü.^ ¦ °ür
Ð
"©#ÅH7jñ#êƒ zïìµ		YþÔ�Õ ,¢>Î¬' kŒ	ÂÀqmí	l	Ø
O�-R—ÈÖÙÄil„»§2<†›‹œCŒ w Ï ²¼ô)1”bš«7¾=‚B~„zF¦= ¾ å 5ƒ‚R¦NïÞ™iêCøa¹\# u Å µ?»Ós¾ËÔêz‚Âçñõ¥ï0Lm{¾"Ð:Ã q½/ ÐAt*·Îê	'	Š	P
È
¥â±u*fKnì�¡åéo|µ¿é*òÖ¿`cy.1<ÅÌä{ { ‘ Èðü
¨ƒ0bS«Äó»dïÑÜ*y¦Ó"”!+  > ¥ +y
êÎyrÍ°´øü r¤ä÷õµ!:ìòq ! Ë&E_e„`”!	�	,
U
fý+fìZzJ¯çà¿8 k Ç VzÒ2;€2jøT	W	{	�	¨	ÿ	
b
PIÀk~Ÿv¤LXZsÐì^oz®Æ•´zj|ýÑùþ×v¾ † Z7~8q±÷Œ7?Ç‚‹Ÿ^Ù�² 3* Y – ² Ê JR�("ßm½Õ	¯
wÑŽ=r£µÌ)x@^¶Í×zÙdüV“ÀbZ/ 3 R /œºˆƒ!:	†ªKY•ÝÂ]ñCíç•ñN^o�2q}ËòÒúq�—Id£Q‹" ; ²é	p	š	c8G9.u{&eh$IÁ÷D[väd‘®õ�µ¾øÉ(/ H Ú “ç¦ýZk„›éW¨É&5AÄû<
Ä
½Áò 0ªÔóK*ØãYfÝ±-sÒ" QÁ@9S¾a¾ÜN	§
­þi§²Ü8~„¯<ügÃÌ¦$§:ß' #M]kÇðöŸ«	ß	�
‚;‘ÏÀ°Ä&/;EP„§‰BÁønW' ¶ ™n‘÷žî^nŒ]óR
ñ
#ÕÞž®`3ŽV¯b”%�~
éµ‹_»2:z´/ ×-1PZÊz–£[¸/	M	g	…	í	¢
29~º]žú$oxM\žïõ·,Ñ"‘ÁæNrF§³ f àxô\	�U î+Ês=Öé�( � ” ¼ ™‚¼h¹›
ú
w`p•“ŸÛçsy¡­³5½:™Öáó_‰8x ,>ä8ä-	e	
_
57ïœ^qé3á³a8;{•ð& « @:ÖßK`´Õ²Îb	»	Î	
Ã\›—ä�£ë”M¯Æº½>OÇ½7}¤$  Ý é4d•@T”ÐòR)	t	¤	4
½Ìä_³éŽTX3R›´MœÅ r™ÆØö�±Ç2	Œ	Ê
.¼Å×Fñf¸ëQ–K‡# r ÛË6Ä!'œãæ
aögñJ¼Šo¥äš!»Ô u
sÊÎ<ˆÏ ) K o �¶Òë"Cvòœ9‡(¦î—QÂÝç	À! B û /Àcæ‘Ý¹}?¹!ß—àòËø6}ÄMË S¥_îNMÏ
ÓŒ¿Ô7=é-  ‹�±»¿óì,ÇÓîyÁ™ª˜ô<¤…¸}Â›‹) z )ÍD	 	‰	Ç
§ü*eRmœ¯Ãä÷®ãîô´ÐÛ bx-0¥æzñp' … .y�›¹Ñ!:z	a
jÐ£JK‹ÁËëµØ]cyØŽpÊøùÿc¢ G "Yè½§è%�h¦ÀÀö­ÂeÜ°´/ Ž “ Ö0w�OYÉ•Zm·»\¸òL	š
ð
ù
"1T�ù2wíU$	r˜ÕàòEŠ¦ºw²19( ª è9cS_×Q±Í�°a	d	£	
3
^
Â^šÄE�eœè•à²ÅWJ¼ïNQ
 Úê¤ñÊbM�Ü†‹¥Óí– Pº6ŸÊÜÉ¿Ã,‡Î" F „ (xŽ°ºçòˆ	ÏdÒI®öÀ˜¿;í
³Áo·÷Û,þšo( ç�N¯¹æñ°Ì
™
ï
0S›Š­Òõ¿Oqì	¹À—ÄÔßñVîD¥Û™†0Í@ } ÐãåæŽØÙM�ïð¯	


./‡ˆ‰CDEWX½¾UÓÞïð()ìí@ABC~£¤ÃÄ–—˜…—©#-./¦§Ì" ~ H	ÑäZ�Ð

(
I
EzPFYV/èü‰*¾ÅÑ$F¨° ÂˆÚÚO™Šô�0
Eê«˜ª¬( I{­ 
~ºå<áj¶Æ—	Ð	)
ªF®	Gs­fWÁ0ß9Ð!Æÿ{%G› x–_‘¯´;'jáHéñ ¨9ak6Ne©±  ¡ [¼ô	<Zei»_ýŠ›æ¿ñð . ­ ÒQÏŠÑ
J
Ý
{�æQU�m%±+ÒÖ a�Ö 
YÅ
_-¼z$p™ ‹ íVn‡ã–Y”	0
þ
ïP…™ûþT	Nž¥Èo¿	­ >Ãð:‰Û})½	ý‹õ 5±ûÊ1Ü0«€ëQÕ«æ BÛJð	šŸÆFéF
B¬(Õ+  +J®/c»=…êGv·Ë!Tþv	Ñ	�
¶Îò{'‹šU[»4NXÂàqWÛá. § |'¬Ú!6Óú–ÿ+.;ñôkn{¿Ya4{HòB®Ô1nšÑ"˜Çä|ƒˆ Ò ƒæfâ-Ò¦- Ïæm¯
t:FË…�ÑHœ& 9 åiû kÇR	j	˜	¦	*
N
¥
'«Gêt}©²ñúmcbg:² ÿA& @  ‹—‰l’ô+	(k¶â–òwÈ4:x² <y&µW,‹„	"Ýê·ºTO©îi7ª ß ')ã$<ÒI©àâf” á `°tN¨¡ZœXblOU�  ¢ í ô o¤÷±ûëœˆE
o
˜ _<«Ó‹çGò0’k€ ñ ÿ P]\ÅÒùrÏ‘f¼ãu5�Àîh! € ¹žL—Bµh>	õ	¼
=k)2P[`iØVþÅ�'žs– Ã q~½pŸ?
>¢27jI�:�hî\œ_ñ1  WV¯
[«|ŽëR­øVÊ¡¦láù‚&,4V<´/ 	×à{ÓÐ*V¤ìX¬ÏuK
j
–
ä
ìdçA£åXÎæKŽN÷6Cn‹²# Ó¢tÔ�w(  / N ® Hõ¦ŒD…æ	6
{
Þ
ˆµÐÄ¶þà/9×%­>ÚÌI\ª×i¶ëô   ¢R‹žÜÿHÒ
<�Ö¶*ÔT}�‘©)T¶0Ûå†Ç  Ö C½˜×Ít�	Å	!
ÁóDwºÚÜ£¯eZdB bb>›ÈÌ
Z)8~�º×ÝQªO{Uq s¨ûLµt	´
ç
HÆ3¡ÌØö±…%šÚ ã ‘îÿ’Ž	:
Ö
¾X¼è`v@�.½0Ï8o�G W]²âìšÿ
_,7Hhš\PíO­Lp“Àö6% , ‰ Œ Ÿ îï]ˆ­äÄZ�®’	•	.
1
í
QÍuhüU
LSæú™£&
® ë :Õ%Fyoè	t†ÚP	m
Ž
´ð†Ÿ”¦áÉ�v’Á ý—8b]"$ÆÚúÿ¡Mµ@# ÄGNÜGa~D÷:W
0ÿ¡´þ­ûöE²þüpõb\iéùç ø ;iü‹
&\Q1¬·R ?�Ë4<ÜŠÈ1*×	‚
’ÜüŒËRìÖ€û # ”ñe$³É¾	”Èõé!6µ"2Ýf“�?×$¬ÚQW › Z—øK	#	Ê	¡õ¦ô˜ˆÊ4aPê—�“In»  `Í©ÝÜ(Ag™qI	ñ	hÛ—Ùî Ç’•8\üf­) *g§1D	Bq†q-|œ>…GWžä°Õ e¬Ctÿx‡Ød–4	Ç›æ‚0¢ÅG‹C‰Öâ/ ¯0€¼­<l#¸4ß<}	
Y
‘
¬
	c�øKt¸K;BGaxƒ¦§,G|Ã&wÆIû6 c ,³†£ëHªÆw’ÃÌåY	w	ã	ê	%
ˆ
Ó
ê
E‘·ÉÒó5ˆ£¾êÐæøp‡Ïª0¼ÚRe—¶lw”*  d“ªÕ�"=-yÀÿž	Ò	
KTÏ2iUàã›>Oá&rk¢Èõ“ïÌ@SÜ2 KTÎ?rÉ5P|¿>†6c)U0è		8	Ý	Nq|(ŒVÎÒ\5Yt‚�¹gÿ@¼^¥lXÇâ" m Ô4—€ƒ	|‹ZºÕ"Œ&“I‰œóÒÖÎ;™å5Ã‰! ¨ Ô7ŒÍKkH_	
G
ÀxÂ%¬÷«¯ °o‡#�ÙÈLm™' 7 ï g­ƒ(¢ ,VŠFžòUh
â
lb¡�˜´Nãa`{Õ§›ÿZ}„é0 ™ é ö Xq}¦ù(’³ýÛí"û/<êÖõ	Õ	€
@oó5²|äòÊZC.È2dmô=Ø( \ ^ jÓ4I§¡ùÐü	Rt‰çLmo†°¶¯Þnuw…Íîr€$ƒ…Ì ‘ Ó Ý©.nÄÏ;K½Óæ†J>Ò� ` „Ägã.d
šÇÊîlþÎ|�„%ô)ŽÐÀI ç£û|q
X ý".yu‘Ÿú5É+G¡"C¹û‚ t Ä jÁQlÒk	(0N€Q~æhéîBl~z!ÏB   ¤ Ç+
O
x
éëª³òûnº´cqÕ)xÒ“ëß' 2 Q X ± É I1Þlp‚S	V	§	þ	
v°Huq\ðB?­Ö³ü�Öu2PŠ/ : Ææüjž8ƒÈ4Ãú™	ª	¦
Ã
¬±¼ÎÛñÿ-ƒd¦#Hˆ;CJË÷�9÷, V'Ñ µ » ˜m*®a“€²Õèˆ³ =“Ôõ,	·`¹³L£ A q ú ŒRL
‰¸n¤ã¾™ 5; !Š€û)lÆ
—ó\xÉwø¡y E ƒ '�v¶·¢	ø
!Œ…Ñ#I‰Â	8 GÁ‡¸-D˜
OBë¸¿îU½ÂÐÚéª„« z^PŒàh^ÞlÏå Ÿðïj =�ì9â•XS^4Û»/nªPÔ  *‚ä.úùþ:zXlŠ¨ðlAm„ãVà@ à (#%k!ÑÜMSßá ó þ ¸öO\ÄgžD
=6;hŽ9ªÒFÄ&ígj•Ÿ" M ßUô«;µ
ÓÉSJ�à=B�Š¨Ù(3UËŸ¡ÚÓv Õ â B¼íKa9
(WçvuÛ©¢®7dTYc + ˆ 9Ô$Exs±Œ�
³Ìtùå’´5€‘ ;MÇ0´ø#úPV _–f	p„¡O[–�ãûe€mº% b Í>qÈ’©Â3,x¿	Ü	é	‡
�œ`Ï=©+œ¸vfHÇô’îRÆ“% ˜ è î õ p¥ø‘²üì'‰éjGF
g
á
?ÔãŽÉz:œþYÂKl˜ [ Ãp
™…É!íÎ�ùÈÍ#*Œ$ó(�¸�  £ Ã i�0‚o»Íþ,¹åAB¬ÔèíAû(8ö+1OU ´ º QÓú`m’½v ¢ D ‚  ]†ŒO·á”¡	÷
‹—ÐßAR]gäˆ¼ÁÏïƒ ò ý -Tøfy gkÑÛA�§'Tž ÙÒßiu~ 8A»^LÆe‹VsæuÚä•â6úd÷¹ù  Â p�ÂÇ&Áèif
>ÓÌÈ+¨¸�)@Æ#'X‘Q— � º…N÷¶“Šö
–_ltÞQ\fjÙÐ»ÎŸØ‚øt¡- Á oÆM$%w|õ
¾¿*abcde¥¦§·Ù�Ž`† !"_�ºÍ÷_`* Ÿ6ŸÞ˜·Cx}©?	ö	½
ß*?À3ÚüaW‡ÿ~þd©Â`(ýaÄ Ì r¸@²	6Á4Ûý;Ž ï+X|¾x±áïç)¨ Í Ê*™åDq±
”Óži ­-\`îþb$ ¾yÙ	„
·
àÞµ38�+ÛkJŠbÿ	j»ªÃ™aò2�	. 1† 7 ß³~ ª×@	÷	@
¾
?£©ß!&@fðA�náÏ]ˆ�ÿRXe†k[¹Å  žP\àS5Ü<W·}'qy²âè©¡ W¹A¬~�ìlªó�§Ëm,YT-Î és³	}@ùË(+Óƒuwì5*G=KNµÜ i Í X°&.7®Âþ¢ïâðú¿\hðW ' +%¥ÿ#eç¤{Á	wÏç�Œ³9Ýs£a»ïx& 
v«Øþ|¸ÔãaWØí­O—
WíCG¹æ“
7•4L¡Ôu&_°c) áUšÑ+EYÐ<	L
º
–Ôè?07YLj°4DouÆ–.]Ùý/��S†$ –gËær¥v…G	k
²
å
•BŸü<Oø—ßó`‘$Íƒ®‘EÕÿ' 0 5 O ¯ 3Š¿�~
ª
Ñ
¸#ª Å$9‘l�‡á_Øc$IÍÔkò j3
 I!øµ7
Ê¶4ˆ¬M kZbØ$ë$ §±zdEˆÚ	ç	…
ß
‰§ÑÜë‹Æ
¼?P8šü]«õSž·ìõY'  % §1öCý†Þs
|
¸
¶áãåß,·ÿK 0:&®«ÄÛJó®„% 2ó£	ðÝíË¶	ø	
€ª
‘g#8BM"o¡~‰’S‡£*Üf°º# ¡¡©àS{ŒÁ«A	Z×áÕñ‘ÕU^¡-ž ªô?1™âæÈ& 8¼€´ŸIÓØÛ¯	A
u
¤=àÿ'â2EÐž€Y�U·Ï¥­\   T ‡E ¡À	¿
@Ô÷·"A[Ž—Öß+Äéfs­Al‡Æ!  × ™ØHÃúm	Æ	Ù
ÊPÂÚTÇÛ&‹¨3³f[úe¢  ŸÎÁßr|n‚á¸	˜Ý¸…~°™é·C�! D¾l�
u	"
‚ôS€»‡£ÃÝ=r‡œ¤ã,FŒh�ª$ Q]¤î	%	£.EÉ×;x6$=XqÅjm€x¼“(z€°•DZ x ™ò½õœŠ	r	Ì	Í
¬í•mw»K¨¬ R«ƒ…À{K Xº­9c›ÞùF¿-C|§Ê  Ð ³ÉïÍ*÷2‚i0Ì8ìZVr²Ï � cc?BÃ	[*�«€šØô�n6>U.J‰PG> „Sœ	ú	è
IÇIOÙðjÌ,¥ÔxºH>Ý €Mêt
¢²jDì ¿ æ 6ƒu
§µ
”4ÍÙúß÷š„ëvùbí†+&O¶› t©ü¶ë´	~A¨E)R6EL]Û v Î ä 4´×
“½ÕéaÃð¦/1÷9ƒp¼ =  ¶“�	‚etYÌëÿ{è£ñö¾;Ä!Ë*¾( j Æ Y' ¼Ô	¿žö(w]ŠÌæ”ðûMU]in1|’¿ÐñÑpŽH½/ P\j’ïõ¥±Û@M;
:¿/8¯Ã%.:DO}gƒòãûAcf�À¥#XÞr$ ß,ígQ
¡
Ý\vLo’žÉÚæî}¶+Ðè�´ÀåM^q7y# Ü +ÞÏ³ãÆ(	‹	É
 ã-²è›ãð]¢êp“P®:z”2=›Æ¼| ( J Ñ!Bu^ &› ›`f8I|>ÞÁßt÷	rèÍÊ1 ¸X C¦$ë	Æ
¦i+g¥¿Q¢í›Âã
xÀêõó£×�Úad/¤¯³båð) � ’ Ùé£wðbÉX^PY[Ž¯ñK	2
™ÛDÎ1cvTHç”—:5ö+Mv+±% | ÏâäŽ®ÙåîË˜
î
R†óV¬ô¼çû/–ÒÝ'¢•",¯ -   w•¬ÿ}¹‰i®Å–	ó	©iºTeð8šÕþz§`d  Š `ÕïUm†(“	/
ý
Xî	„ýÅMEÉ¤,AÔ#o'å) ¦ &b«ÿ Òé,F*u,ýQ	M
�
jµñzés±ùTZ3M±EpÊ—‚ŒÚþ‡ ? &;Šâs•v§¶
Ç3íwT“# ì n£°úp}›‡Ñ=	>
n
»
—1ÎH×Œâ/^0‘rÂ* ÖGVz
�ë	ZÛªCz
ë‡ÏÕ@Ã¬µý)8W ¥åkøMö5"/hä;Žó —Ìss³
æ
C»2 ×Ö°PÎN„ŒFA \ç…Ã7a™­‘	-
l
^#gÙ[Kù˜ ¢à¬%uÀ " ÊFhF`9V
%þÇÛôúû ýôa’[h¶ÖèÙ# «Ì¨þ¦'fw†˜c•"	C	H	g…–,í{=”`Ä¯’á Ô5 S4O{¾¢;©bŽ
<Þ;7	X	|	â	
X
«
Ò
D1Js¢é:w¥÷FÑÙd{%–µÅþkú]jk+ 6 l WÓ‚‹3¡UEÕ‚	
¹Á$«! %’³MYˆâ`ªÿ_¯ÇcØló<4è×% i3Høc
Qsˆlµÿ®ÆüÃmtží4ýqJ{‚ƒ Òÿ!ú¿- 1 P W ° È ÅHÀÝ�3PkùU	©	 
w
Â
¯ /‚[³Gp‡>Iök}Ž ÎÕwÑê ù <K·­	±[_¸² 8¶ CN3]ÎÚ©Ù  õ["jÃùý9C
5‰	:�8@ÈŒlR2%ì ‡ :Jr	8
Œ
²'Ëøƒ ‘­³cS4% Z — Ì=‘¨�n2+F¾	Û	è	†
à
âý�ìÍ*ä@yÇA·Ìe9›ýíT ³ @,KS‹àexŠÚ@”&Scö¸% ž5Ý¶#{À‰ Ò)>^sÇÝ¤¶Œ_Øý¨ÁW^¹×�öü^$ Ë É)²Ö±	Ø	ƒ
°
“¨ÒÝ´Þ� %Îþi{½QW°æ¬[§ŸíZ �%ß?k©-~ò¶î'Ò[gpvJÛ+ & •f„þ";	F	¹
•æ>¸ ;	¯3–Þò_�”3ÅÌÜKr‚�Ø%Œ¯R…% $ 4 02÷B‰c‡´Ý}
©
¦·âäÉ‡«Lê€†^#YO~ÓûôR­X+  S ¨ò»DÀÊÚ®	¿	t
àÓöZ–Þ"7LÃ!1Dè r€¬ó@˜áe¤¯  GÞù{£$	·	¢É:Æ#p†¢%ÂwŠ’¯˜+E”¶ùgY  œ ˜
ñ‰îÌ	q	Â	Ë	«öh/v™JøEë5Iˆ¿±JÉ ê›	ù	
§H“ØDi¤QëD2 < 3O[iô¤³ÚL	�d’9�õ$-9CN|'f\‰Ëåbe“úTö‘¤‚ÝÊo¼)»/ I Û  ÞÝBšfÅ 
Å
Ü[âï¾¡‘šÈÙâ=’ô¢Ùä]Þqš®²çÉ# _”è¢ÎávTl…�hXÊ'J	ò	˜Ú…ò–9DÈ.+õ@ýn*ä% %m‰¢a¯ùªþ|œê)©Bü=
iÂ«(GSÖV‹2L	2gã.‹  ÉªE§[Â6r˜¬B	„Øóùº1ÖÕ“_ÃŸ«Zg‹tØÓ0 V R½�¡:h ¨2T	ÔÝO6	á	v
Á
Cr‡®r.èÂ²�©3F†=H�Äj‚�Ÿ;ÐÖ  ô9ÂJ	B
B92°Í¨± +µ€¿°	ÿ³Ýá $(]Æã?ýh§¯%åV¸¦] Ab¿ÙÜE	­	¨
¥>=j¨Ò}…ÑŸXZuà®  NhFzˆÙ¢Á	È’œ×C,Å…£êùHDCXÈ% $^lˆÈ®øDue—Ÿ
ƒø¹„�™Øá'<FRŠ1CÂÇpŠmŠ×ã  U ó 5	¬	à	À
A<ÑçÁ#\±Å1¨itŒ®%  fgñò­÷ yž
ÐÕÖ¸Bƒ�˜×à0QÆghBoˆ‰Ç  1ü  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                       )                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   	               
                           	                                                                                  $                            $                                                                                             +                                            	                                       *                                                                       	                      !               
            
         :   +            
                                 	      	   	         !               
      
                              2   '      '   #      1   &       )   –   a               -      h                                                                                                                                                                  )                                                                                                                                                                                                                                                                                           	     
           	                            $          $                                   +                	             *                         	        !     
    
   : +    
           	  	 	   !     
  
          2 '  ' #  1 &   ) – a     -  h   ƒS  „·  „Ý  …  ŠG  �‹  —¿ Ë—/ $AÝfÙE	°	C=ÁNi‰¢+Ùë‘¨>˜gC�	ü
¡é6ÑJ ¸d¸Üöõœd–G"FÖFMÇµÕxK¥åññm
Ë¡6Ñ6¨«óE	¾ MÇçkƒ»	�	¨uvŽËÍ÷0«ó&u{sÇÞioä7BÃïC†ø1µ'}¿Ç÷ö3	.>ˆšÇ÷­'.L>Ç÷.>.šÇ÷­Ç÷.ßb'‘	gëgC3;ÚA‘Ùäœ
Øy7ÒÄçl
Ë 
jÙÞ	Ù êäÍÖ Ÿß
ü„•jÛ,�	!² �	N]
ß±…ÝÇ^›
ûŽ£tßžçÜá°RP©êZ‰Z Û¼­r§ú´Ù}LSÜÝ¶	æ-…G”!Ê”%d>Áeïy�¤Éå“¾„Š$™U	E$ÒYt(Ç~ »;YüÓÁÿ¯Ø)íæ
r§ú´>�?Ž[Ù‹ã Éø G -šï­‰Þ ÞFˆÈkÅ�ÿ \fãî°¸+~ $^S
d�H¥ÞUÒ ý-š€�„¨WëPÒvÛ>�ÖÃd°r°ø:´RšŽ(¢Vh
â
b¡ã:W
E<pjÃ³Ò‘4>º�K½ 4
³Ê” %d»ýæ>ÁÇ	î	œ
ežØû5�ïXdy”Ü�¤Éçm–i·X	µà ˜9	3K¯²q1	Ö†Kæ
 °aF ñ:ùXy‰Ýerü5	J	›	à	Ÿ
Ür«ÈÉHç�ØSv°Å%2ÄiÝ¶	¡—*f¨dy›/#	¡9Áv‘“.	}¹�ÚE$™á{	Iv¤zùE$r²G˜Å»aüS2Í  -š$^S
d€�„¨WH¥ï­ë‰ÞÑ–†ÉLaXüJ	S°2¦OXc	]
ß±w Mz~¼mNl	Ä
­uNb½nr 9�°åøÐ«íó<@v‘ø‚Øý*±arü›	HS2+P	r°øÉK  ¤ýƒä	4
³ŽÞ-#«GR¨´´ÅÏ 17V¬ øÌFþôèFÈÅ…¶–»Î‚p–ƒó£#8BM£Ü-šÓX	Áÿ¯µØ)à ˜íÆ
›ãa/U	 
Õ»²úâç }VSÜŽÏ ç Àä}é
V4½�ÔåLSèÞÜ  Í +a€ÑŸÝOÓE¶	À	Ñ
ß
ìCá‘æ“ÏØ+c�é
O²8šüL–™†  ã S‡?a �Î9v‘ëi+�¢ê¼	p	uI¾k³i¢ê}SÜ‹k	39K¯;eêËš É	ô—3Hc•áq©¯t,|) Ò"Cv.!5|6ž	ã>�áÜ  ¤Íýsƒä	”
Þö-#«G¨´ ¡þG�|œ Sµ…ÆR½Þ¡:¨	Ýf6	á	 
CÜr[è‘ÈÙÄä]j¦ür
ƒq˜Å1	»Öê†Ç ·€2jêø	T	¨	ÿ	¥~*fìZ¿éoòÖj|`c.väØ Ly_on	È	Þ	œ

ŸÙüa¤6��¨†m¼Í«FGùz¢ÈÉÅÆ…%ŠDùXe 	]	Ó	
võ–¥v…G	•<®‘ÿyoÈ	ŸÙ¤†Í«·ê	¥*fì¿éòÖ`c.äÇ €2jøT	¨	ÿ	~Zoj|vœê©BÂ«(VLgã„Ê Su	Í&™º	Dw¯éš	Gh; Ç ²·€2jêíø	T	¨	ÿ	¥c~*-8fÈÖì{&Ze¿Äéilo[»äòdÖj|õ�`c.vÉäC(R½ÞFG¡:¨ù	zÝf¢6	á	 
CÜrÈÉ[è‘ÈÙÅÆ…%ŠÄä]jDùXy
êÎ´ü¤ä÷õ!:ò8 hi	¥	¤
&|ba9Na:W
0¡öE\iI  š=ÞqçÉØ¤h	£
%%y{ð¹Ò˜�ÛÕ)/ä& þ"æÜrl 3‚	¹!%’ˆ4š1ÙùÇ	žØÃŒ�ÕC½]G÷tš!
_7H¦´óþ­ûºüpÜP£êÀöù& l ³ 3þ"¶‚	 ¹æ!%’ˆÜr4 &›`fIt	rÍFF`9V
þúýôa[hèþ‘�	Õ
½?Ž/n\NhÙœ,ùÂl	Ø
OÙ§2¬ “d#Îío²ÈÎ
Ü
“¡åÒègí![€$e°<>Ã	Øô)>R.ELÛÞ5 ž	ŠðíËà~
ª¸ç#ª $‘g‡Üá_·}9‡èkò°»3°	³Ý$ýh¯å¦Õ/È”lºœøì¹7Žëd	Ô	ò±Uåñû-ã.máùD~Ó© 8RÖ`	c	]
Á]Ãdß±»P±§¼P«žìYíÎ
Ò<“d#²È“è!e>	Ô	ò±ñû-D¬ ÎoÜ
¡ågí[€$°; ²íc-8ÈÖ{&eÄil[»ädõ�ÉC(F F`&›9V
`fþIúýôa[ht	rÍè§ 6¿®n"Ç™DÓi-\ Í�Bø	
v Î ä 4´×
“½ÕéaÃð¦/1÷9ƒp¼< 3O[iô¤³ÚL	�d’9�õ$-9CN|'f\‰Ëåbe“úTö‘¤‚ÝÊo¼)»kŒ	ÂÀqmí	l	Ø
O�-R—ÈÖÙÄil„»§2<†›‹œCŒ* Ô Óì#Dw•/o³"… .y�›¹Ñ!:z	a
jÐ£JK‹ÁËëµØ]cyØŽpÊøùÿc¢u Å µ?»Ós¾ËÔêz‚Âçñõ¥ï0Lm{¾"Ð:Ã q½ù <K·­	±[_¸²   ¡®¥)U£W‹ÎþGt„å	5
i
•
ã
c´ê�¢ßä÷.|ÍÖ$œ¬ HS[©µs…³µÆêÙ LÀ?šRV`½		o	Þ	œ
ýb7F�©7tz®%ÓZu)×âô¦m½ÈGÞù{£$	·	¢É:Æ#p†¢%ÂwŠ’¯˜+E”¶ùgY¦ &b«ÿ Òé,F*u,ýQ	M
�
jµñzés±ùTZ3M±EpÊ—‚ŒÚþ‡G … • Ù "LU.6Qy}�›¹ÀÑ?Y‡!šè7R½:V`§½è%1i÷		9	o	z	€	Þ	a
œ
®
O�ýbj}Ð7Fh�¦À…�£©<JX©7K”ÜWtz‹¢®´ÁË%6>YrÆÏÓë]n�ÀìöZuyžµÅy”Ø]cy­ÂØ){Ž×âôpÊøýe¦±Üùam–°´½ÿYc¢È ? ¦ à &(*;‚Šâä&.b#%k«úÿ Òéù,Fþ*:u,ýQ	M
�
jzµñXlzésŠ!¨±ðùTlÑAZs3M•m±ÜEMpv§¶Ê
SÇ„—ßáã3V‚ŒÚàíþ@wT‡“s¨ûLµt	´
ç
HÆ3¡ÌØö±…%šÚ  ¤ Ç+
O
x
éëª³òûnº´cqÕ)xÒ“ëß ¡ [¼ô	<Zei»_ýŠ›æ¿ñðAb¿ÙÜE	­	¨
¥>=j¨Ò}…ÑŸXZuà®e ó˜öy��¢]‹.	[	f	„	ì	8}Œ¹Ô­_�#_n�[”rx� ¬ô4¼!9<€^D ‚  ]†ŒO·á”¡	÷
‹—ÐßAR]gäˆ¼ÁÏïƒf … s¨û*Lµ.y�›¹Ñàxô!gt§1:	D	\	z	a
´
ç
BHq†�ÆUq -jÐî+£3J|¡ÌØKÊ‹ÁËœëö>…±µGsØW]cyØŽ=pžÊÖéø�äù…°ÿ%c¢šÕÚW¹A¬~�ìlªó�§Ëm,YT-ÎÝ  )o       Ù        Ù¿þ`�îÒu¸îód¥=&ã¿ŽˆŠ,á$ŒÄÕjS�uC¡ñÖ�…ã¤
C*Œã¬Æ'Ñ™Ì¡Úhy)¥’[Zpi+dý™�+Ì§eéÂVÏƒ‡Ï×üý¡ËYaÉŠý’\õ�¯hrÖšœ%xýè4�µ"m˜õ'?ù¡ËXp•ƒóàÚcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'.fSDîàåäEýã§ƒ¦ÅigÞdSƒ“*W¥:	ñ;ö<Í;àù§­Á8Paô-UI»˜ö0îñ…{¶Fm‡³­aEƒîü©o]=ÒÔb�]¬”/káƒ¸U¶�àn‚ëêÅ®0#RØEWÑb·`KÄ*aßôEÛ#pÒ=:¨mŠ8HøjØTmAÔRŸˆ·*º¯£×[Õdao†ß�Õ1©S�A4bWŽ—TöÕS˜c×l“ˆ!aÝ 7Øaøƒ˜qôÞ!K†ÛàßXèç`AxCv†à�A@b&ÖtX> GivðtJ‡@FGÀû_àUÓŠ„Q‚Ò‰èN
Ç†ù-FP@û¦¡@Á·üŽßÄ*]ô†"ÓÛE”>÷XõEo‡óàòñ†"í/MÊ�ö‹¶¬í=z8÷xöè_>2uwô8Á÷
±Á»©Ôstšü2¯uåè#ÑïŒëï»H4ÃP�`‡ ùó ñ4ßGø;j÷íõcŽ!EcÄ`N á4suÖ<‚”c�ï¬¼{ñÀ|E‚ºàn�õ«ÈŽ8!VòHTEÂcuÔnsÚù¡[c@Þ Q8¨mÚ.øÛ¸zèv mPÿA�¸·+¶¯ãÓGàsn†Ü�Õ©C]2ÜbK~žPÆUA¨~ ƒˆ-qÝ 7ØaøŽ˜A?~!
¶ŠðÓXøç`AQr`� @4b6×`H > \¸fÐwyÇG‚kùXàÕ	„Q†Ò	‰øVËÍvélzßQ@kî¼@Ñ»„s…À6êõ*îí!ñ¤Þ;Ð¼o½4ä.MøÆ&û-GHŒ½7N"ÐØ8ÂˆFótAà|¸X‡ˆ�Àw¹Ôëow®ô[c}!Ax·Õb\‹ëï‹„4ÃPÏí· 20§7D54ûiÔqÆRH@ü©_ÎO±â>¹(ôöâŠ�ûÿ#ëè�B=ïÞ/«å•ahÛ6‹„�‹kšà € M@GY468Œ ;˜:áÓ€;�o÷3ø“ÚS0Àˆ §3L‡Îw£Ó?“?;êÎ®¿¯«³Ü¬ðêÿ-Nål ïê@¯’:œ7ìÕW¡¤`­É =³ødpª³ú‡(÷+©d�îŠõx]í›°¹®¨jeª<jÃæ‚•V†¥ÕZ—1ikˆ"-) T¿ÐïôÐÑI�ScnÖ’Ó_B T¿ÐïôÐÑI�ScnÖ’Ó_d¿?åï?oÏù{ÏÒ¼ý®óýƒ‡–ª©©�ñ>ãîšôRHAª��ê�U;ð¢fö«áµÐaÊ³a¡u74+¼<èkaà7]l8îóÈ¯-3@3ð®ª-GÇâð�áaxÐq3lƒƒÜp2¾ŒÓˆìr‹xS@x8æ€Å#À4¾-»~Žøñ&öØ8cXÃ6s¡¼9øý¬}õ1]³lLMÉìðº,m�Åm ìÏOŠÏCµÍ�ÇA»,‡öcã£Å›`�V:®¶Çˆ<8ƒÎmdÊ!š8Q:1`8|ëìŽ§	³Îük4Í³ë›>ºJë„À{€+‡ÇÔÇ?_�mÄjÆ½óÏ®aP :Álªððàa¾ôÌ»c�+¬ýÿ^Šš4é–
ueMdÛujÝYSjªÞ6¹(‚¢õ{mbn›bâgË¹9 Ém‚Ù8«â!Z)¼íÖ½Ývq<ÙR%O€#å„„åíÚZ2Œíãó«ÒÀWâÈôãial=s0C
Œš;¯:û;x{8ÎÂÊÃŒ10›NÞÕ%œ)½Ñm eÍEØ„ÕCÓUA|•Pó(àÊ«ÙóÿáÄÛuVÇ;RÑ1_ÇAæTgÐÊ¿øïìŒîø¯ãÎŸ~/>®þ°È3«¶NÜâBnÒ°‰+;Ôà8ˆÜ_ÿ+OÇÎ3é¼%æË¡/_ÂQÜzl÷ƒM=à—A¤Ñ1	‰#�º‚—œ9ÞEI¨&ã;Žô§ëTJ	;¡¼5u}ó‚L*ª*54Ñ§3EUA»QFú†ê¹À.í \UíÊP ¶¦ÕPn·äoªV•XR©[[•&fW ¸t§Ö:[HC~nÓ‹š²¶öJ>ÿ,‰yÆp:}¸?Ò8ÖóýÎßôjm5•ôôðP<LÑH/�z›Ï½½.ih£ÀS‘%$¬ô¥’£5Ê(öŽt6È"Üì² ˜:ÚÓ¼+õÆÔ1)ØoýŠ#US
NúÂûÆÊ-” óH¦ÞØ)ƒMãe®éâØöòQŽ«ˆx!'µõ-®d‰Œ1ñ(î�Ã-g–|ÏvM©TŽÛhrºÀ1W»PnŸ8¡Ò±‰{#^­6êž­ôÊ¸MUÐPÕcÍU@Y@ÇpV(Yížëê­fšÚ›@¦‹¶vj&¤Ueud¼ÍÚ¿ÅR=ør  ¦  d   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  <?xml version="1.0"?><Features recycledIDs="16" nextValidID="18"><Feature recentID="17" name="HK1" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3718" maxFusedRunOn="3718"><Segment range="935-3685" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="15" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="6023-6039" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="T7 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="863-881" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="6092-6113" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="6047-6053" color="#ffffff" type="standard"/><Segment range="6054-6071" color="#ffffff" type="standard"/><Segment name="-35" range="6072-6077" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8018-8122" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5829-5950" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4645-4780" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="615-818" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="bGH poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3753-3977" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4465-4794" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="235-614" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4023-4451" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6401-6986" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="Neo" directionality="1" translationMW="29047.90" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4861-5655" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="1" name="AmpR" directionality="2" translationMW="31557.36" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7948" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="7157-7948" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7949-8017" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="FLAG" directionality="1" translationMW="1012.98" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3718" maxFusedRunOn="3718" detectionMode="exactProteinMatch"><Segment range="3692-3715" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;FLAGÂ® epitope tag, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>c2a67142-87fc-47fc-8749-39c4819a275d</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.5</Created>
<LastModified UTC="3:10:25">2021.3.31</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  &     e  L         L¿þ`�îÒu¸îód¥=&ã¿ŽˆŠ,á$ŒÄÕjS�uC¡ñÖ�…ã¤
C*Œã¬Æ'Ñ™Ì¡Úhy)¥’[Zpi+dý™�+Ì§eéÂVÏƒ‡Ï×üý¡ËYaÉŠý’\õ�¯hrÖšœ%xýè4�µ"m˜õ'?ù¡ËXp•ƒóàÚcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'.fSDîàåäEýã§ƒ¦ÅigÞdSƒ“*W¥:	ñ;÷’ôˆ ZãFoMÒ<ìA§PaÇI!ò¥8m>Çˆúä£ÓÛŠ*?ïü�¯¡þ÷¿x¾¯–U„£lÚ.B-®k€ €45 hdÐØà0€î`ë„0T_N î@	¿ÜÏâL3iLÃ ‚œÍ29Þ�LþLüï«:ºþ¾®Ïr³Ã«üµ;•°¿©¼jHêpß±ÿU^†�!‚·$€öÏá‘ÂªÏê KÜ®¥’º+Õà]wµþnÂæº¡©”¨ñ«š
UXN—Uj\Å¥® Xˆ´¤�RÿC¿ÓCE&5M�»ZKM}�RÿC¿ÓCE&5M�»ZKM}’üÿ—¼ý¿?åï?Jóö»ÏöZª¦¦4CÄ<û�¸NkÑI!:ª>Cª5TïÀN‰›Ú¬†ÔGA„*Í†…Ô`hÜÐ®ðó  D9¬9‡€Ýtu°ã¸cÏ"¼8´Í ÏÂº¨µ‹Â?……ãAÄ4Ì9²qÀÊú3N#±Ê-áLàãš� Ðnø¶íú;ãÄT›Û`á�c8ÙÎ†ðçãö±÷ÔÅvÍ±17'°`SÂè±´nM´³=<^+=Ô36?1ì²Ø1�Ž�m‚X<ê¸Û ðà"9´“(9ü†háDè0Å€áó¯²:œ&Ï;ñ¬Ó6Ï®lúèq+®î ¬VSý~=·«÷Ï>¹…B€ë²«ÀsÃ�†ûÓ0íŽ®³÷ýz*hÓ¦X)Õ•5“mÕ«ueMª«xÚä¢
‹Õíµ‰ºm‹‰Ÿ,~ääNƒ%¶dâ¯ˆ…h¦ó·Z÷uÙÄðSeH•> �–—·ihÊ3·�Î¯K_‹#Ó�¥…°õÌÀ*2hî¼ëìíáìã;+0ÄÂm;{T0–p¦÷E´—4bUMT=òUCÌ£ƒ*¯d;Ïÿ‡mÕ[íKD Å™QŸC*ÿàS¿²3»â¼�:|ø¼ú»úÀS Î®Ù;s‰	»JÂ$,¬ïS€â#qü­?8Ï¦ð—›.„½	Gqé³Þ4÷‚]“DÄ&$0ŽtJèR>^pçy]& ›Œî8SÒŸ¬Q($î†ðÕÕ÷Î	0ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I^‚áÒŸXém!ù»Ln.jÊÛÙ(ø{ü²$eçÀ@éöàÿHãXgÌG÷;|;Ñ©´ÖWÓÓÁ@ñ3E ¾5êo>öô¹¥¢�ND”’³Ò–JŒ×(£Ú9ÐÛ ‹s²Ê‚`ëkNð¯×PÄ§a¿ö(�UL);ëï(´RRƒÍ"›{`¦7�–»§‹cÛÉF:®!à„ž×Ô¶¸E’&0ÇÄ£º?µœYó=Ù4^¥R;m UÊë Å^íAº|â„oJÆ%ýì�ýxn´Ûªz·Ó*à!5WACU�5UeÁX¡g¶{¯ªµšhSjmš.ØLÙ¨Xš‘U•Õ�
ó7jÿH÷áË   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  b<?xml version="1.0"?><Features nextValidID="17"><Feature recentID="16" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="895-990" color="#ffff99" type="standard"/></Feature><Feature recentID="15" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3322-3338" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="T7 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="863-881" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3391-3412" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="3346-3352" color="#ffffff" type="standard"/><Segment range="3353-3370" color="#ffffff" type="standard"/><Segment name="-35" range="3371-3376" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5317-5421" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3128-3249" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1944-2079" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="615-818" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="bGH poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1052-1276" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1764-2093" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="235-614" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1322-1750" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3700-4285" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="Neo" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2160-2954" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="1" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5247" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4456-5247" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5248-5316" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="FLAG" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1017" maxFusedRunOn="1017" detectionMode="exactProteinMatch"><Segment range="991-1014" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;FLAGÂ® epitope tag, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ><Notes>
<UUID>c2a67142-87fc-47fc-8749-39c4819a275d</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.5</Created>
<LastModified UTC="3:10:3">2021.3.31</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  &      p  v         v¿þ`�îÒu¸îód¥=&ã¿ŽˆŠ,á$ŒÄÕjS�uC¡ñÖ�…ã¤
C*Œã¬Æ'Ñ™Ì¡Úhy)¥’[Zpi+dý™�+Ì§eéÂVÏƒ‡Ï×üý¡ËYaÉŠý’\õ�¯hrÖšœ%xýè4�µ"m˜õ'?ù¡ËXp•ƒóàÚcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'.fSDîàåäEýã§ƒ¦ÅigÞdSƒ“*W¥:	ñ;÷’ôˆ ZãFoMÒ<ìAçT}‡i•aÛuaÔ’?*Wó†Óìx�®J==¸¢£þÿÈúúàP�{÷‹êùeXAZ6Í¢á$"Úæ¸  AÓP€QÖMŽ cæ¸CEôàä ›ýÌþ$Ã6”Ì0")ÌÓ!ó�èôÏäÏÎú³«¯ëêì÷+<:¿ËS¹[ ;ú�+Æ¤Ž§ûõUèi+rHlþ*¬þ¡Ê½ÊêY {¢½^×{_æì.kª™@j�°ù ¥U„á©uV¥ÌZZâˆ‹J@ˆ/ô;ý44RcTØÛµ¤´×Ðˆ/ô;ý44RcTØÛµ¤´×Ù/Ïù{ÏÛóþ^óô¯?k¼ÿ`áåªªjcD<CÏ¸û„æ½’Cª Cä:£UNüè™½ªÁ¸mDtA²¬Øh]F�Í
ï:CšÃ˜x×G[;†<ò+Ã‹LÐü+ª‹Qñø¼#øX^4CLÃ› à÷¯£4â;¢ÞÀP9 1Hðï‹nß£¾<EI½¶Ö0Ã�œèo~?k}LWlÛr{<.‹A†àqDÛ@;3ÓÅâ³ÐíC3cñÃnË!ýƒøèñfØ UƒÎ«�­±â Áó›AÙ2ƒŸÈfŽNƒX:û#©Âló¿Í3lúæÏ®‡ºá0à
Åañõ1Ï×ãÛq±¯|óë˜T(°[*¼<8o½3 nØàJë?×¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸™òÇîNDè2[`¶N*øˆVŠo;u¯w]œO6T‰Sàùa!9{v–Œ£;xüêô°ø²=8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êí“·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘EÒj	¸Îã…=)úÁU‚Nèo]_|à“
ªŠ�M4iÌÑUPnÔQ¾¡º®p‡;H{r”¨-„iµT­ùê•¥VªVÖåI™„•è.)õŽ–Òß›´Æâæ¬­½’�‡¿Ë"F^qœŸnôŽ5†|Äs·Ã½›Me}=<4Rã^¦óïoKšZ(ðäII+=)d¨ÍrŠ=£�²·;,¨&¶´ï
ýqµJvÿbˆÕTÂ“¾°¾ñ²‹E%(<Ò)·¶
`ÓxÙkºx¶=¼”cªâIí}Kk„Y"c|J;£ðËYÀeŸ3Ý“EêU#¶Ú\®°UîÔ§Î(Fô¬b_ÞÈß×†ëMº§«}2®Ut5XóUPP1ÜŠ{gºú«Y¦…6¦Ð)¢í„Á�š…‰©Y]Y ¯3v¯ñT�~  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ‡<?xml version="1.0"?><Features nextValidID="17"><Feature recentID="16" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5289" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4498-5289" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5290-5358" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="Neo" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2202-2996" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3742-4327" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1364-1792" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="235-614" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1806-2135" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="bGH poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1094-1318" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="615-818" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1986-2121" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3170-3291" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5359-5463" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="3xFLAG" directionality="1" translationMW="2730.72" type="CDS" allowSegmentOverlaps="0" cleavageArrows="1056" consecutiveTranslationNumbering="1" maxRunOn="1059" maxFusedRunOn="1059" detectionMode="exactProteinMatch"><Segment range="991-1056" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;three tandem FLAGÂ® epitope tags, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="3388-3394" color="#ffffff" type="standard"/><Segment range="3395-3412" color="#ffffff" type="standard"/><Segment name="-35" range="3413-3418" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3433-3454" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="T7 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="863-881" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3364-3380" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="895-990" color="#ffff99" type="standard"/></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>4ff05e09-b66c-469c-8065-75f8cff75ce8</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.5</Created>
<LastModified UTC="10:9:41">2019.11.8</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  
0ý7zXZ  æÖ´F !   t/å£àJ(	î] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷ÀnÉ;_xŠÉ	÷ý…ešðŠ�m°ÐÄü}ævô³cñ¸ëhrkÝ@‡áœƒV<h¹ˆÜ÷÷ƒ"s›n„ƒÌþëä¥e
Œ”ò6ÖÅs`L[N5u´=V†ž”>#«�ÿŸªÜ:SbçÅÄÁ‡Ð,gêHž»o¿®„+oã¾jõIÏ»­_˜�Ðfp-z.®‚hi+¼ØŽôÔ�eÙ8RÒÔ¹ëÞÜÅö÷µ"¹[á‚UHÞ–Ä$OôíX/þè®Ø¢lrðÿ.#âU)$JÔ’êÛ˜usA<.ÞZÆŠž¾Òç¾4qû}Ä„�f'áu­¿fôúA`‡¡üK¨_®ÞöyA§äÛv{\ôî¶Þâz2;4×(%“~˜)‹5zEpÛêEXÎ.WÍâØ>oÀÉ�ils¾‚êoÌJàÏÍéÂ|Æ'«*ƒ!0ùÌþêË†�]�0j~\3‰ï^ÆÓ»EŽá½Tûa™ƒ•ñàÕ¨hshÄÐazpÅ’ef˜õÀš/¥p=¿L[Òø¬5ÕöžÝF,Ì1µÕþ9ÁâµÞ³”»k~��bÖBE* Jõ÷Ù‰eC®fX¯†ÍDÅ%ûõiçç:Ä`s8�P*2IAzÉ-zsÁüå©çPõx®ˆŽyýºÆJÂ�ŒN4ã>M<)o oºYD€u0ý=ß‡Øõþ7ê½);¾áEfå3’ÿÏÓ‚cîfÊƒåô5gžr{DëqÎ_Î”ÛÊö§šZ�eŠ@u^…Eº‹9>;ZMÍJ¾·8²·‰á¢tùÄ…G9&±0	­ÒwõìQ¿ÕïMwWŽ„è…2„·8oleêÖ÷ßð�±Îu§Ë¹eMßè:úÀ‹ÓÅŸµ¡±HÜ":ËªMwØ0É�å�úàF¦!¤Ê÷—�er² «ß¶q`ƒF~7)-‘FW·Ì»:úä~òXZfE!¹½÷õ|·o›Ðm{ì¦»2nþ®ò÷ðOÖ“Þ}÷8’y�ªào—_ä£“Ê€–UÇÝt
Ò‹r½³ñÿ 5æêÃF‹½*œ50D§¯4j:m[ÎRT×jg—~ k°'Án-Á‹cš@ôå?úþrBà±r\ÐE™ãë÷÷Õùi$)�øõ½¥§–s7…**+P·|&•ÆÚºüíÃé	­¸æï3¸õÞê©L¦¼uyìÒèèW*	EZ_c$vC¦ Knªç?ù{ÏáAFS©·wËD¬Íãw]A¬]^,œ%?ýl´À!·xå‡bŸÖcÖn{Û}Á5«¥ùÉ¤cÝªÂ}–Åp%³Ûô½‡ƒöü„Ôf….»ý­Î(•Ú½ p£G:eÔ*Í•£(¥&Tp¹/D�i†WŸ¹mÆpÕ�ÓGÅQê|X�uæ€ŽÉxAÀz“Ã!nSI† äBƒ¯~{˜¢ T¼z	Í8»IZgfCO8*ÆŠÞ}£XŠèk®q1:Á‘,4¢\Pkâ÷3g:ág¥ÞÛW¤†ãdžßQù½]~øÉ-6£l‰¼: Jî
Qá¦Q^'õ/ì<‚]þñ%Xf«qð“íÏ3/ÎÄ…„ü¦–³)?R[úª«ë)3`C¾ï+8y 9¨&GüwÂÌ5zåœW'^4¡‚áqÅáuÄI–;lˆ6`.ñ"V=Ôp¢ñÝJõyKO´x oêFyæ˜›~‘ý”ÖšŒ\¹Ïã@¢²ÏÊ£]®Í	¼6ƒ$iP¹{µ“S<‘2Âý•)*SDû|!ïšÅPVî�š… c!�H%ŽÇtsC•ÒÌÂ>W¥õ5ñ?Ž¥!ä™êÃ¬ú`øa‚†ÀCT.ËUÙ¹."ú‹„fæ[”{HZÄ2G¾!c¶ÇPGlnÞo`ïyæñM)”-‰‰íµßV“Ûó’ï÷Íõ©0èRçKÆ¢ü£”·Fƒ¾F¥NÒ93èÀ0×Øo|®Õà5s„‰¨H¹ºýIÙ›è Ü„¡yïy�ãHÙ!§/¹cîøÞYÝÕ8‘6±ÔòP-¡˜÷_“öÆeá=óóÌ½CEßè´¤A1ôÍ5Éï¤ß£0iÂiãÕÒËBßŒîs÷ˆn:?Ënuš[Š
�íð¦^ËZ™OÜ«holmº=+
ŒTmzšÏá²�“!êã[/ÎëZ.ÚQL#¯„ã[#{½Yev	V‰J+Û‘Ü2Q“=q‹¨à´TèsÔ)èœ>*â§öW8d@†BLÛ
W;žWÿÔµMçz	]}suŽ�Œ§�ï\Â¢^žíóú²X{rßŽÒž�}!û‹#!ƒëžâÙïJwÇ¥@{ç�”»}7"l�8d@4øH¨â™o#kèß/ŽæsêiAa5aå/í!Í£ŽlOXqÕPjË,®(LÑ!»�íBæYÉÔÎŸpT¶AÄRbW%Caçž^èK"¯»x  îø-|]o”V¤š5ð™÷à¯óëWsæTŒVÞÂò¥íóYÞÏÃìüH]‹>C[ðÚçè±ò–$e_ò¹hµÝ�B®æ–Ït¤Miß€¹÷ßÅ>n’yLÍÃ“Ÿ‚B›²¹�4Wó²FÛ²Wþjvµ˜qæ´ç�ófAŒv\¼¾UBp®n£Á­i
—sï|)]0Pú]E±§Ý*Rš\€”bÏ\1%;kÚeè}5Kí"H†ÆˆŽ5�D †‘e›½žQ
Üæf+* b‹Ð-¶<èîh´°°…ïø{f*ÉTOžò�~ Å¥«.¹f×és.2æÔ ³Û4³kˆØzhö“¢ß&‰›ô«ÿ¶—…¢Z|HD$Êßw‚hÔD`~ÿ<V-6d�®Œd%é…Ò(z‡„•‡)¡Òs5×®œ¡°}Ï'š‚‡yžB:QôÞŸÛ)%g¬5¦Â¤ºAÎhäŸä¬œà3w¢ƒ<Á†Sä:¹!–K<2óîQíÏ{þ±z©\ÊÙ`‡Lûû˜z RsÃ°ŒUÅ¿ž§ö[õ.4ARGyp‡KãÓtå¡4?O^H,<ÓºÎ@‹ûFÁ ×[ëÈ/ïi¹Ho-Gç¼tú›a¦Ô	G[˜Åº~°ÑŠ›ðÇÀ�ãŠ­<…«nk›‘T[ÑÖùÖé&õÓhÉAŸ¸Ü¶»$¤ä!/Ç�é]œê¹åˆ.�¿;Fx)OÙ ôÉ:º0r¦tûO8Wý³ñÄà.µžŒÜöÔþM~*x7]YÇ{Ü;u—’ÅÓ²    Bã“ÄÄdÜ“ Š©” Ã¥|:±Ägû    YZ   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  $<?xml version="1.0"?><Features nextValidID="17"><Feature recentID="0" name="FLAG" directionality="1" translationMW="1012.98" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3724" maxFusedRunOn="3724" detectionMode="exactProteinMatch"><Segment range="3698-3721" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;FLAGÂ® epitope tag, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="DYKDDDDK"/></Q></Feature><Feature recentID="1" name="AmpR" directionality="2" translationMW="31557.36" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7954" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="7163-7954" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7955-8023" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="2" name="Neo" directionality="1" translationMW="29047.90" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4867-5661" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQGLAPAELFARLKARMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF*"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6407-6992" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4029-4457" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="235-614" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4471-4800" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="bGH poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3759-3983" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="615-818" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4651-4786" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5835-5956" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8024-8128" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="6053-6059" color="#ffffff" type="standard"/><Segment range="6060-6077" color="#ffffff" type="standard"/><Segment name="-35" range="6078-6083" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="6098-6119" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="T7 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="863-881" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="6029-6045" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="HK1" directionality="1" translationMW="102488.44" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3724" maxFusedRunOn="3724"><Segment range="941-3691" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ¡<Notes>
<UUID>2d702014-d382-4e3e-a0e2-48e002b95bf2</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pCMV-HK1(human)-FLAG-Neo</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="16:0:0">2017.6.5</Created>
<LastModified UTC="7:44:56">2025.9.3</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y     K         
?????                                                                                                       ÿ d      DO  d              E              ÿÿÿÿYô? P                                                                                                                                                              ©<StrandColors><TopStrand><ColorRange range="0..8158" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..8158" colors="black"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
